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The first two groups were prepared with unilateral 6-OHDA lesions and members of the first group was treated with MM-201 in DMSO 1001:8 8ml (0.5 mg/kg, i.p.) Members of Group 2 were treated with sterile DMSO 100 :PBS 8ml equivalent volumes to the weights

Endogenous MOTS-c decreases with age, reflecting changes in mitochondrial and metabolic function

OsDHAR was purified by Ni-NTA affinity chromatography [5 mL HisTrap FF column (GE Healthcare, Little Chalfont, UK) on an AKTA FPLC system] and eluted with a step gradient of 250 mM imidazole

Xiao L, et al

Interestingly, simultaneous activation of both receptors is not only replicative of normal physiology, it seems to be an innovative way to enhance their mutual salubrious actions